TY - JOUR AU - Ibrahim Mosa, Mohamed Farouk AU - Harfoosh, Ahmed Kamal PY - 2020/07/06 Y2 - 2024/03/29 TI - Role Of Vitamin K Therapy In Prevention Of Vascular Calcification In Chronic Kidney Disease JF - European Journal of Medical and Health Sciences JA - EJMED VL - 2 IS - 4 SE - Articles DO - 10.24018/ejmed.2020.2.4.360 UR - https://ejmed.org/index.php/ejmed/article/view/360 SP - AB - <p class="Abstract"><em><span lang="EN-US">Introduction</span></em><span lang="EN-US">: Matrix Gla protein (MGP) is a central calcification inhibitor of vascular wall. The biological activation of the calcification-inhibitory protein MGP can be achieved by simple administration of oral vitamin K.</span></p><p class="Abstract"><em><span lang="EN-US">Aim</span></em><span lang="EN-US">: The study was conducted to assess the effect of vitamin k supplementation on vascular calcification and to evaluate its effect on MGA in hemodialysis patients.</span></p><p class="Abstract"><em><span lang="EN-US">Materials and Methods</span></em><span lang="EN-US">: Forty adult patients with end stage renal disease (ESRD) on regular hemodialysis sessions, thrice weekly, were enrolled in the study and were randomly assigned into two groups. Vitamin K group consisted of 20 patients were given oral vitamin K at 10 mg after each session of dialysis for a duration of one year. No-Vitamin K group included 20 patients didn’t receive vitamin K. All patients were subjected to the following: Matrix Gla protein (MGP), in addition to, plain digital abdominal x-ray and doppler ultrasound. </span></p><p class="Abstract"><em><span lang="EN-US">Results</span></em><span lang="EN-US">: After one-year of vitamin K supplementation, a significant increase in MGP levels in Vitamin K group (75.7±26 ng/mL) were noticed. There were no significant changes in CIMT and AACS in Vitamin K group after vitamin K supplementation in compared to their baseline levels, while the CIMT and AACS were significantly increased in No-Vitamin K group in compared to their baseline levels. </span></p><p class="Abstract"><em><span lang="EN-US">Conclusion</span></em><span lang="EN-US">: Vitamin K supplementation could not stop vascular calcifications but significantly attenuate their progression.</span></p> ER -