COVID-19 Infection in India: Seropositivity versus the Dynamics of the Spread


  •   Zameer Shervani

  •   Deepali Bhardwaj

  •   Roma Nikhat


The self-referred serosurvey data showed that the whole of India, 31% population has SARS-CoV-2 antibodies. Seroprevalence was higher in females (35%) than males (30%). The seropositivity in Ahmedabad, Jaipur, Bangalore, and Delhi increased monotonously from July to December. Seropositivity in big cities of India was as high as 63.8% in Bangalore followed by Delhi (54.9%) and Kolkata (54.6%). In cities (Mumbai, Chennai, Pune, Coimbatore, Surat, Visakhapatnam, Kolkata, and Nagpur) antibodies prevalence first increased with time after a threshold it started decreasing in 4 month time in most of the cities. Intergeneration age dependent seropositivity for both males and females showed an “M-shaped” pattern. The seroprevalence versus monthly infection rate in Delhi and Kolkata showed an increase in seroprevalence with the caseload. In Chennai, the caseload of new infections decreased while seropositivity increased. In the case of Mumbai, seropositivity increased with increase in the caseload in the beginning till October, after that with decrease in the caseload seroprevalence also diminished. In none of the cities, the amount of antibodies titers was enough to stop the second wave of the pandemic.

Keywords: COVID-19 serosurvey, First and second COVID-19 waves, Herd immunity, Seroprevalence in India, SARS-CoV-2 spread


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