A Case of Stiffperson Syndrome

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  •   Mamdouh H. Kalakatawi

  •   Nusrat Aziz

  •   Norhan A. K. Mostafa

Abstract

Stiffperson syndrome (SPS) is one of the rarest neurological disorders. It is an autoimmune disease with antibodies against glutamic acid decarboxylase - enzyme needed to produce neurotransmitter GABA. This disease is very debilitating and fatal if not managed in time. A 32-year-old man presented with stiffness of abdominal and thoracolumbar paraspinal muscles first noticed 10 months back. There was history of jerkiness of hands. After excluding other mimicking conditions like multiple sclerosis, parkinsonism and axial dystonia, a diagnosis of Stiffperson syndrome was made. Treatment with IVIG therapy along with anti-spasticity drugs resulted in improved patient outcome. SPS is potentially treatable though cannot be cured. Not one treatment fits all patients with SPS and may have to be tailored according to the clinical manifestations. Increasing awareness in medical doctors and identifying the disease early can help the patients escape the disabling effects of SPS and improve the quality of life.


Keywords: immune disorder, IVIG therapy, rare neurological disorder, Stiffperson syndrome

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How to Cite
Kalakatawi, M. H., Aziz, N., & Mostafa, N. A. K. (2021). A Case of Stiffperson Syndrome. European Journal of Medical and Health Sciences, 3(3), 52-54. https://doi.org/10.24018/ejmed.2021.3.3.871