Langerhans Cell Histiocytosis of the Temporal Bone in Children: Two Cases Report


  •   Y. Labani

  •   O. Oulghoul

  •   O. Benhoummad

  •   Y. Rochdi

  •   A. Raji


Langerhans cell histiocytosis is a rare hematologic disease due to multiplication and accumulation of Langerhans cells, which are immature dendritic cells. The clinical presentation is highly variable and can range from isolated, self-healing skin or bone lesions to life-threatening multisystem disease. We report 2 cases confirmed by Histological and immunohistochemical evaluation of temporal bone biopsies. The first case is a 2-year-old child with chronic bilateral otorrhea and polyuria-polydipsia syndrome. Physical examination showed bilateral retroauricular redness and induration with filling all of the right and left external ear canal. Computed tomography showed osseous lysis of the temporal bone bilaterally. Magnetic resonance imaging of the brain showed the presence of pituitary infiltration. The second case is 2-year-old girl with chronic left otorrhea. Clinical examination objectified the presence of redness and induration in the left mastoid with the presence of an inflammatory polyp filling the entire left external auditory canal. Computed tomography revealed a left temporal bone lysis. Both patients were treated with chemotherapy.

Keywords: Children, Langerhans cell histiocytosis, Temporal bone


Papadopoulou M, Panagopoulou P, Papadopoulou A, Hatzipantelis E, Efstratiou I, Galli‑Tsinopoulou A, et al. The multiple faces of Langerhans cell histiocytosis in childhood: A gentle reminder. Molecular and clinical oncology. 2018;8(3):489-92.

Leung AK, Lam JM, Leong KF. Childhood Langerhans cell histiocytosis: a disease with many faces. World Journal of Pediatrics. 2019:1-10.

Modest MC, Garcia JJ, Arndt CS, Carlson ML. Langerhans cell histiocytosis of the temporal bone: a review of 29 cases at a single center. The Laryngoscope. 2016;126(8):1899-904.

Majumder A, Wick CC, Collins R, Booth TN, Isaacson B, Kutz JW. Pediatric Langerhans cell histiocytosis of the lateral skull base. International journal of pediatric otorhinolaryngology. 2017;99:135-40.

Zheng H, Xia Z, Cao W, Feng Y, Chen S, Li Y-H, et al. Pediatric Langerhans cell histiocytosis of the temporal bone: clinical and imaging studies of 27 cases. World journal of surgical oncology. 2018;16(1):72.

Radojkovic D, Pesic M, Dimic D, Petkovic TR, Radenkovic S, Velojic-Golubovic M, et al. Localised Langerhans cell histiocytosis of the hypothalamic-pituitary region: case report and literature review. Hormones. 2018;17(1):119-25.

Allen A, Matrova E, Ozgen B, Redleaf M, Emmadi R, Saran N. Langerhans' cell histiocytosis of the temporal bone in an adult with central diabetes insipidus. Radiology case reports. 2019;14(7):847-50.

Guo Y, Ning F, Wang G, Li X, Liu J, Yuan Y, et al. Retrospective study of Langerhans cell histiocytosis in ear, nose and neck. American Journal of Otolaryngology. 2019:102369.

Modugno G, Brandolini C, Magnani G, Ferri G, Sabattini E, Pirodda A. Langerhans cell histiocytosis: bilateral temporal bone involvement in an adult with diabetes insipidus. B-ENT. 2010;6(1):67-72.

Jezierska M, Stefanowicz J, Romanowicz G, Kosiak W, Lange M. Langerhans cell histiocytosis in children–a disease with many faces. Recent advances in pathogenesis, diagnostic examinations and treatment. Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii. 2018;35(1):6.


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How to Cite
Labani, Y., Oulghoul, O., Benhoummad, O., Rochdi, Y., & Raji, A. (2021). Langerhans Cell Histiocytosis of the Temporal Bone in Children: Two Cases Report. European Journal of Medical and Health Sciences, 3(3), 24–26.

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