Gastric melanomas are usually metastatic, and primary is almost rare entity.
Present case is a rare malignant melanoma of the gastric region with barely reported cases in the literature. A 65 year old male presented with pain abdomen and melena He was evaluated with relevant investigation. UGI endoscopy and PETCT shows large polypoidal irregular gastric mass in the proximal curvature extending upto gastroesophageal junction. Endoscopic biopsy a ulcero-infiltrating tumour, Individual cells are large, round, having moderately pleomorphic, hyperchromatic nuclei with prominent eosinophilic nucleoli and moderate eosinophilic cytoplasm. Immunohistochemistry of S100 and HMB45 was positive and negative for CK7 and CK20.
Early diagnosis of primary gastric melanoma allows for better prognosis of the patient from the right intervention.
Lagoudianakis EE, Genetzakis M, Tsekouras DK, et al. Primary gastric melanoma: a case report. World J Gastroenterol 2006 July 21; 12(27): 4425-7.
Callaghan GM, Kellher FC, Crowther S, Alakkari A, Ryan BM. A case of primary gastric melanoma exhibiting a rare BRAF V600R mutation. Eur J Case Rep Intern Med. 2018; 5(3): 000749.
Elsayed AM, Albahra M, Nzeako UC, Sobin LH. Malignant melanomas in the small intestine: a study of 103 patients. Am J Gastroenterol. 1996;91:1001-1006.
Chang AE, Karnell LH, Menck HR. The National Cancer Data Base report on cutaneous and noncutaneous melanoma: a summary of 84,836 cases from the past decade. The American College of Surgeons Commission on Cancer and the American Cancer Society. Cancer. 1998;83:1664-1678.
Tabaie HA, Citta RJ, Gallo L, Biondi RJ, Meoli FG, Silverman D (1984) Primary malignant melanoma of the small intestine: report of a case and discussion of the APUD cell concept. J Am Osteopath Assoc 83:374–377.
Horowitz M, Nobrega MM (1998) Primary anal melanoma associated with melanosis of the upper gastrointestinal tract. Endoscopy 30:662–665.
Anupama R. Primary gastric melanoma: a rare cause of upper gastrointestinal bleeding. GastroenterolHepatol. 2008; 4(11): 795-7.
Song W, Liu F, Wang S, Shi H, He W, He Y. Primary gastric malignant melanoma: challenge in preoperative diagnosis. Int J ClinExpPathol. 2014; 7(10): 6826-31.
Augustyn A, Leon ED, Yopp AC. Primary gastric melanoma: case report of a rare malignancy. Rare Tumors. 2015; 7: 46-9.
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