Notable Variants of SARS-CoV-2


  •   Hassan Naji


The current coronavirus pandemic has brought many deaths and affected economies around the world. The causative agent of COVID-19 is identified as SARS-CoV-2, a close relative to SARS-CoV that caused an outbreak of severe acute respiratory distress in 2002-2003. During the course of the pandemic, there has been many reports of mutations that occurred to SARS-CoV-2 with several lineages that has been identified around the globe. In this paper, a summary of the notable variants of SARS-CoV-2 is discussed.

Keywords: SARS-CoV-2, COVID-19, Variants, Lineage, Lineage B.1.1.7, Lineage B.1.351, Lineage B.1.1.207, Cluster 5, 501.V2 Variant, P.1 Variant, SARS-CoV-2 Genome, non-structural proteins, NSPs, Open reading frame 1ab, ORF1ab, Furin


World Health Organization. (2020). Weekly Epidemiological Update - 29 December 2020. Retrieved February 15, 2021, from

Lu, R., Zhao, X., Li, J., Niu, P., Yang, B., Wu, H., Tan, W. (2020). Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. Lancet (London, England), 6736(20), 1–10.

Pereira, F. (2020). Evolutionary dynamics of the SARS-CoV-2 ORF8 accessory gene. Infection, Genetics and Evolution.

Centers for Disease Control and Prevention (CDC). (2021). Genomic Surveillance for SARS-CoV-2 Variants. Retrived February 15, 2021 from

Weisblum, Y., Schmidt, F., Zhang, F., DaSilva, J., Poston, D., Lorenzi, J. C. C., Bieniasz, P. D. (2020). Escape from neutralizing antibodies 1 by SARS-CoV-2 spike protein variants. ELife.

Koyama, T., Platt, D., & Parida, L. (2020). Variant analysis of SARS-cov-2 genomes. Bulletin of the World Health Organization.

Voloch, C. M., da Silva Francisco, R., de Almeida, L. G. P., Cardoso, C. C., Brustolini, O. J., Gerber, A. L., de Faria Cavalcante, L. T. (2020). Genomic characterization of a novel SARS-CoV-2 lineage from Rio de Janeiro, Brazil. MedRxiv.

Rambaut, A., Loman, N., Pybus, O., Barclay, W., Barrett, J., Carabelli, A., Volz, E. (2020). Preliminary genomic characterisation of an emergent SARS-CoV-2 lineage in the UK defined by a novel set of spike mutations. Virological.Org.

Gu, H., Chen, Q., Yang, G., He, L., Fan, H., Deng, Y. Q., Zhou, Y. (2020). Adaptation of SARS-CoV-2 in BALB/c mice for testing vaccine efficacy. Science.

Kemp, S. A., Datir, R. P., Collier, D. A., Ferreira, I. A. T. M., Carabelli, A., Harvey, W., Gupta, R. K. (2020). Recurrent emergence and transmission of a SARS-CoV-2 Spike deletion ∆H69/V70. BioRxiv.

Wu, K., Werner, A. P., Moliva, J. I., Koch, M., Choi, A., Stewart-Jones, G. B. E., Edwards, D. K. (2021). mRNA-1273 vaccine induces neutralizing antibodies against spike mutants from global SARS-CoV-2 variants. BioRxiv : The Preprint Server for Biology.

Collier, D., Meng, B., Ferreira, I., Datir, R., Temperton, N. J., Elmer, A., Gupta, R. (2021). Impact of SARS-CoV-2 B.1.1.7 Spike variant on neutralisation potency of sera from individuals vaccinated with Pfizer vaccine BNT162b2. MedRxiv.

Wibmer, C. K., Ayres, F., Hermanus, T., Madzivhandila, M., Kgagudi, P., Lambson, B. E., Moore, P. L. (2021). SARS-CoV-2 501Y.V2 escapes neutralization by South African COVID-19 donor plasma. BioRxiv : The Preprint Server for Biology.

Korber, B., Fischer, W. M., Gnanakaran, S., Yoon, H., Theiler, J., Abfalterer, W., Montefiori, D. C. (2020). Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus. Cell.

Horby, P., Huntley, C., Davies, N., Edmunds, J., Ferguson, N., Medley, G., Semple, C. (2021). NERVTAG note on B.1.1.7 severity. SAGE.

European Centre for Disease Prevention and Control (ECDC). (2020). Detection of new SARS-CoV-2 variants related to mink. ECDC: Stockholm; 2020.

National Institute of Infectious Diseases, Japan. (2021). New VARIANT strain OF SARS-CoV-2 identified in travelers from Brazil. (2021, January 12). Retrieved February 15, 2021, from

Sabino, E. C., Buss, L. F., Carvalho, M. P. S., Prete, C. A., Crispim, M. A. E., Fraiji, N. A., Faria, N. R. (2021). Resurgence of COVID-19 in Manaus, Brazil, despite high seroprevalence. The Lancet.

Resende, P. C., Bezerra, J. F., Teixeira de Vasconcelos, R. H., Arantes, I., Appolinario, L., Mendonça, A. C., Siqueira, M. M. (2021). Spike E484K mutation in the first SARS-CoV-2 reinfection case confirmed in Brazil, 2020 - SARS-CoV-2 coronavirus / nCoV-2019 Genomic Epidemiology - Virological. Virological.


Download data is not yet available.


How to Cite
Naji, H. (2021). Notable Variants of SARS-CoV-2. European Journal of Medical and Health Science, 3(2), 44-47.