Ectopic thyroid tissue is ubiquitous in the body, most frequently seen at the base of tongue, accounting for approximately 95% of reported cases. Branchial cleft cyst, a congenital abnormality, can occasionally harbor thyroid tissue inside the cyst. These ectopic thyroid tissues can develop the same disease as the orthodox thyroid gland, including the malignant diseases. Papillary thyroid carcinoma arising in the branchial cleft cyst was extremely rare, total of only 14 cases were reported in the literature. Herein, I report additional case which was discovered incidentally after surgery.
Noussios G, Anagnostis P, Goulis DG, Lappas D, Natsis K. Ectopic thyroid tissue: anatomical, clinical, and surgical implications of a rare entity. Euro J of Endocrinology 2011; 165: 375-82.
De Felice M, Di Lauro R. Thyroid development and its disorders: genetics and molecular mechanisms. Endocr Rev 2004; 25:722-45.
Balasubramaniam GS, Stiwell RG, Kennedy JT. Papillary carcinoma arising in ectopic thyroid tissue within a branchial cyst. Pathology 1992; 24:214-16.
Sagit M, Gokler A, Akin I, Han U. Wrong egg in the usual nest: Thyroid papillary carcinoma within a branchial cyst. ENT-Ear, Nose & throat J 2013; 92:E31-E34.
Hong YT, Hong KH. Radiologic features of papillary carcinoma in the second branchial cleft cyst. Ear, Nose & Throat J 2019: 98:295-98.
Matusmoto K, Watanabe Y, Asano G. Thyroid papillary carcinoma arising in ectopic thyroid tissue within a branchial cleft cyst. Pathol Int 1999;49(5):444-6.
Sidhu S, Lioe TF, Clements B. Thyroid papillary carcinoma in lateral neck cyst: Missed primary tumor or ectopic thyroid carcinoma within branchial cleft cyst? J Laryrngol Otol 2000; 114(9):716-18.
Fumarola A, Trimboli P, Cavaliere R, Coletta I, Veltri A, Di Fiore A, et al. Thyroid papillary carcinoma arising in ectopic thyroid tissue within a neck branchial cyst. World J Surg Oncol 2006; 4:24.
Mehmood RK, Basha SI, Gharreb E. A case of papillary carcinoma arising in ectopic thyroid tissue within a branchila cyst with neck node metastasis. Ear Nose Throat J 2006; 85(10):675-76.
Lanzafame S, Caltabiano R, Cappellani A, Thyroid transcription factor 1 (TTF-1) and P63 in two primary papillary thyroid carcinoma of branchial cleft cyts. Virchows Arch 2006; 449(1):129-33.
Park J, Kwon SY, Kim NH, Baik SH,Choi DS. Papillary thyroid carcinoma arising in a branchial cleft cyst. Thyroid 2010; 20(3):347-49.
Cho JS, Shin SH, Kim HK,Lee Js, Park MH, Yoon JH, Jegal YJ. Primary papillary carcinoma originated from a branchial cleft cyst. J Korean Surg Soc 2011; 81(suppl 1):512-16.
Kuhwaha JK, Sonkar AA, Goel MM, Gupta R. Papillary carcinoma of thyroid arising from ectopic thyroid tissue inside branchial cleft cyst: A rare case BMJ Case Rep 2012 July 9;2012.
Karras S, Anagnostis R,Noussios G, Pontkides N. Thyroid papillary carcinoma arising in ectopic thyroid tissue within a branchial cleft cyst. BNJ Case Rep 2013 Apr 22; 2013.
This work is licensed under a Creative Commons Attribution 4.0 International License.