Epidemiology and Prevalence of Type 2 Diabetes Mellitus in Children with Obesity

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  •   Vidit Kulshreshta

  •   Syed M. Shahid

Abstract

The epidemiology and prevalence of Type 2 Diabetes Mellitus (T2DM) in today’s youth and tomorrow’s adults, is currently in alarming stages and goes hand in hand with Childhood Obesity (CO). This association causes detrimental impacts on child health and around 68% global population today are affected by it. T2DM is initiated in children with obesity as insulin functioning is resisted, which further leads to an inflammation and damage in the pancreas leading to adverse effects in later stages of life. Many scientific studies have been conducted to understand this link and does Body Mass Index (BMI) contribute to this epidemiology and complications related to T2DM and Obesity in children. Alarming effects, both physically and internally on the pancreas are observed because of these conditions and also causes fat deposition in the body organs like pancreas leading to increased Body Mass Index (BMI) and Waist Circumference (WC). This association can be caused due to genetic factor during infancy, but this has still not been validated as relevant researches are still underway. Important studies like SEARCH for Diabetes in Youth have contributed to giving important and useful findings about this association but still much needs to be achieved to make future progress in overcoming this burden on child health and ensure that Sustainable Developmental Goal (SDG) 3 is achieved at a global level.


Keywords: Body Mass Index (BMI), Childhood Obesity (CO), Insulin Resistance (IR), Type 2 Diabetes Mellitus (T2DM)

References

Valaiyapathi, B., Gower, B., & Ashraf, A. P. (2020). Pathophysiology of Type 2 Diabetes in Children and Adolescents Current Diabetes Reviews, 16(3). https://doi.org/10.2174/1573399814666180608074510.

Kim, S. Y., England, J. L., Sharma, J. A., & Njoroge, T. (2011). Impact of Maternal Obesity and Diabetes on Long-Term Health of the Offspring Journal of Diabetes Research 2011, 9. https://doi.org/https://doi.org/10.1155/2011/541308.

Galuska, D. A., Gunn, J. P., O’Connor, A. E., & Petersen, R. (2018). Addressing Childhood Obesity for Type 2 Diabetes Prevention: Challenges and Opportunities. Diabetes Spectrum, 31(4), 330-335. https://doi.org/https://doi.org/10.2337/ds18-0017.

KayeWooton, A., & M.Melchior, L. (2017). Obesity and Type 2 Diabetes in Our Youth: A Recipe for Cardiovascular Disease. The Journal Of Nurse Practitioners, 13(3), 222-227 https://doi.org/https://doi.org/10.1016/j.nurpra.2016.08.035.

Zeng, C.-P., Lin, X., Peng, C., Zhou, L., You, H.-M., Shen, J., & Deng, H.-W. (2019). Identification of novel genetic variants for type 2 diabetes, childhood obesity, and their pleiotropic loci Journal of Human Genetics, 64, 369–377. https://www.nature.com/articles/s10038-019-0577-5.

Davies, N. (2018). Type 2 Diabetes and Obesity: The Link Diabetes Self-Management. https://www.diabetesselfmanagement.com/about-diabetes/types-of-diabetes/type-2-diabetes-and-obesity-the-link/.

Silink, M. (2010). The challenge of childhood obesity and diabetes The Lancet, 375(9733). https://doi.org/https://doi.org/10.1016/S0140-6736(10)61015-X.

Fang, X., Zuo, J., Zhou, J., Cai, J., Chen, C., Xiang, E., Li, H., Cheng, X., & Chen, P. (2019). Childhood obesity leads to adult type 2 diabetes and coronary artery diseases: A 2-sample mendelian randomization study. 98(32). https://doi.org/10.1097/MD.0000000000016825.

Abbasi, A., Juszczyk, D., van Jaarsveld, C.H., & Gulliford, M.C. (2017). Body Mass Index and Incident Type 1 and Type 2 Diabetes in Children and Young Adults: A Retrospective Cohort Study Journal of the Endocrine Society, 1(5), 524–537 https://doi.org/https://doi.org/10.1210/js.2017-00044.

Eriksson, J. G., Kajantie, E., Lampl, M., & Osmond, C. (2015). Trajectories of body mass index amongst children who develop type 2 diabetes as adults Journal of Internal Medicine. https://doi.org/https://doi.org/10.1111/joim.12354.

Jensen, E. T., & Dabelea, D. (2018). Type 2 Diabetes in Youth: New Lessons from the SEARCH Study. Curr Diab Rep, 18(6). https://doi.org/10.1007/s11892-018-0997-1.

Hamman, R. F., Bell, R. A., Dabelea, D., Jr., R. B. D. A., Dolan, L., Imperatore, G., Lawrence, J. M., Linder, B., Marcovina, S. M., Mayer-Davis, E. J., Pihoker, C., Rodriguez, B. L., & Saydah, S. (2014). The SEARCH for Diabetes in Youth Study: Rationale, Findings, and Future Directions Diabetes Care 37(12), 3336-3344 https://doi.org/https://doi.org/10.2337/dc14-0574.

Goss, A. M., Goree, L. L., Ellis, A. C., Chandler‐Laney, P. C., Casazza, K., Lockhart, M. E., & Gower, B. A. (2012). Effects of diet macronutrient composition on body composition and fat distribution during weight maintenance and weight loss The Obesity Society, 21(6), 1139-1142. https://doi.org/https://doi.org/10.1002/oby.20191.

Bloomgarden, Z. (2018). Diabetes and branched-chain amino acids: What is the link? J Diabetes 10(5), 350-352 https://doi.org/10.1111/1753-0407.12645.

Tricò, D., Prinsen, H., Giannini, C., Graaf, R. d., Juchem, C., Li, F., Caprio, S., Santoro, N., & Herzog, R. I. (2017). Elevated α-Hydroxybutyrate and Branched-Chain Amino Acid Levels Predict Deterioration of Glycemic Control in Adolescents The Journal of Clinical Endocrinology & Metabolism, 102(7), 2473–2481. https://doi.org/https://doi.org/10.1210/jc.2017-00475.

Michaliszyn, S. F., Mari, A., Lee, S., Bacha, F., Tfayli, H., Farchoukh, L., Ferrannini, E., & Arslanian, S. (2014). β-Cell Function, Incretin Effect, and Incretin Hormones in Obese Youth Along the Span of Glucose Tolerance from Normal to Prediabetes to Type 2 Diabetes Diabetes Care, 63(11), 3846-3855 https://doi.org/https://doi.org/10.2337/db13-1951.

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How to Cite
Kulshreshta, V., & Shahid, S. M. (2021). Epidemiology and Prevalence of Type 2 Diabetes Mellitus in Children with Obesity. European Journal of Medical and Health Sciences, 3(1), 39-43. https://doi.org/10.24018/ejmed.2021.3.1.693