Prevalence of Obstructive Sleep Apnea and Impact of Menopause on It among Women of Rural Area of Pakistan

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  •   Sana Mansoor

  •   Tayyab Mumtaz Khan

  •   Maira Naseer

  •   Sania Saher

  •   Farwa Shabbir

  •   Munazzah Kaleem

  •   Syeda Aimen Waris

  •   Mubashira Kiran

  •   Madeeha Mumtaz

  •   Hina Mansoor

Abstract

Obstructive sleep apnea (OSA) is a common sleep related disorder, and it is affected by number of factors including age, gender, obesity, educational status and menopause. However, in the presence of conflicting findings regarding impact of menopause on OSA, our study was aimed to check the prevalence of OSA in women and impact on it of menopause. This descriptive cross-sectional study was conducted in around 3months from August 2020 to October 2020 in a rural area of Punjab, Pakistan. 205 participants were recruited according to set criteria of our study. Women with age from above 30 years to 60 years, who had regular menstrual cycles or had cessation of menses since at least one last year were enrolled in the study whereas women who had irregular menstrual cycles and were not willing to participate were excluded from the study. Data was collected by two questionnaires including self-structured proforma and STOP Questionnaire. Data analysis was done with the help of SPSS version 25. Different tests including Chi-square test and Independent Sample t-test were applied to evaluate the study variables. In general, current study indicates high prevalence (28.3%) of high risk of OSA among women, however, STOP score was higher among postmenopausal women (1.641 with SD±0.908) as compared to premenopausal women (1.073 SD±0.693)) which means that postmenopausal women had higher risk of development of OSA in comparison with premenopausal women. The association between OSA risk and menopause was statistically significant (p=0.001). The difference of score between premenopausal women and postmenopausal women was significant statistically (p=0.0001). In short, prevalence of OSA high risk is higher among postmenopausal women in comparison with premenopausal women and menopause affects OSA but the mechanism is still not clear.


Keywords: Prevalence, Obstructive sleep apnea, Impact, Menopause, Women, Rural area, Pakistan

References

Theorell-Haglöw J, Miller CB, Bartlett DJ, Yee BJ, Openshaw HD, Grunstein RR. Gender differences in obstructive sleep apnoea, insomnia and restless legs syndrome in adults–What do we know? A clinical update. Sleep Medicine Reviews. 2018 Apr 1;38:28-38.

Shochat T, Pillar G. Sleep apnoea in the older adult. Drugs & aging. 2003 Jul 1;20(8):551-60.

Banno K, Kryger MH. Sleep apnea: clinical investigations in humans. Sleep medicine. 2007 Jun 1;8(4):400-26.

Hongyo K, Ito N, Yamamoto K, Yasunobe Y, Takeda M, Oguro R, Takami Y, Takeya Y, Sugimoto K, Rakugi H. Factors associated with the severity of obstructive sleep apnea in older adults. Geriatrics & Gerontology International. 2017 Apr;17(4):614-21.

Foroughi M, Malekmohammad M, Sharafkhaneh A, Emami H, Adimi P, Khoundabi B. Prevalence of obstructive sleep apnea in a high-risk population using the stop-bang questionnaire in Tehran, Iran. Tanaffos. 2017;16(3):217.

Schwartz AR, Patil SP, Laffan AM, Polotsky V, Schneider H, Smith PL. Obesity and obstructive sleep apnea: pathogenic mechanisms and therapeutic approaches. Proceedings of the American Thoracic Society. 2008 Feb 15;5(2):185-92.

Dancey DR, Hanly PJ, Soong C, Lee B, Hoffstein V. Impact of menopause on the prevalence and severity of sleep apnea. Chest. 2001 Jul 1;120(1):151-5.

Block AJ, Wynne JW, Boysen PG. Sleep-disordered breathing and nocturnal oxygen desaturation in postmenopausal women. The American journal of medicine. 1980 Jul 1;69(1):75-9.

Block AJ, Wynne JW, Boysen PG, Lindsey S, Martin C, Cantor B. Menopause, medroxyprogesterone and breathing during sleep. The American journal of medicine. 1981 Mar 1;70(3):506-10.

Antonijevic IA, Stalla GK, Steiger A. Modulation of the sleep electroencephalogram by estrogen replacement in postmenopausal women. American journal of obstetrics and gynecology. 2000 Feb 1;182(2):277-82.

Keefe DL, Watson R, Naftolin F. Hormone replacement therapy may alleviate sleep apnea in menopausal women: a pilot study. Menopause. 1999 Jan 1;6(3):196-200.

Popovic RM, White DP. Upper airway muscle activity in normal women: influence of hormonal status. Journal of Applied Physiology. 1998 Mar 1;84(3):1055-62.

Cistulli PA, Barnes DJ, Grunstein RR, Sullivan CE. Effect of short-term hormone replacement in the treatment of obstructive sleep apnoea in postmenopausal women. Thorax. 1994 Jul 1;49(7):699-702.

Millman RP, Carlisle CC, McGarvey ST, Eveloff SE, Levinson PD. Body fat distribution and sleep apnea severity in women. Chest. 1995 Feb 1;107(2):362-6.

Joffe H, Massler A, Sharkey KM. Evaluation and management of sleep disturbance during the menopause transition. InSeminars in reproductive medicine 2010 Sep (Vol. 28, No. 5, p. 404). NIH Public Access.

Perger E, Mattaliano P, Lombardi C. Menopause and sleep apnea. Maturitas. 2019 Jun 1;124:35-8.

Jehan S, Masters-Isarilov A, Idoko Salifu FZ, Jean-Louis G, Pandi-Perumal SR, Gupta R, Brzezinski A, McFarlane SI. Sleep disorders in postmenopausal women. Journal of sleep disorders & therapy. 2015 Aug;4(5).

Koo SK, Ahn GY, Choi JW, Kim YJ, Jung SH, Moon JS, Lee YI. Obstructive sleep apnea in postmenopausal women: a comparative study using drug induced sleep endoscopy. Brazilian journal of otorhinolaryngology. 2017 May 1;83(3):285-91.

Carskadon MA, Bearpark HM, Sharkey KM, Millman RP, Rosenberg C, Cavallo A, Carlisle C, Acebo C. Effects of menopause and nasal occlusion on breathing during sleep. American journal of respiratory and critical care medicine. 1997 Jan;155(1):205-10.

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How to Cite
Mansoor, S., Khan, T. M., Naseer, M., Saher, S., Shabbir, F., Kaleem, M., Waris, S. A., Kiran, M., Mumtaz, M., & Mansoor, H. (2021). Prevalence of Obstructive Sleep Apnea and Impact of Menopause on It among Women of Rural Area of Pakistan. European Journal of Medical and Health Sciences, 3(1), 99-102. https://doi.org/10.24018/ejmed.2021.3.1.683

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