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We report clinical characteristic, imaging studies, and management of a rare case of expansion epithelial malignancy due to squamous cell carcinoma (SCC). A man was admitted with protrusion of the left eye due to orbital medial tumor mass. The patient had undergone removal surgery, chemotherapy, and radiotherapy two years ago. Imaging and histopathological studies were conducted to determine protrusion of the left eye due to Non-keratinizing sinonasal SCC. The left eye exenteration was conducted and continued with the chemotherapy procedure. This case demonstrates that even aggressive and repetitive surgical may not be adequate in preventing worse outcomes.

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