A Narration: 20th v/s 21st Century: Pandemic v/s Another Pandemic: Virus v/s Another Virus (Spanish Flu V/S COVID-19)

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  •   A. Saulat

  •   A. N. Jafri

Abstract

Pandemic leads to major mortality and morbidity. Many pandemics occur over the centuries, but the mother of all pandemic was "Spanish Flu" and nowadays we are facing another huge uncontrollable "Covid 19" pandemic of the current century. The purpose of this comparative review is to help and provide guidance for frontline medical staff in dealing with this current outbreak to differentiate and seek information with the previous pandemic and get knowledgeable guidance for future dealings of COVID-19. Peer-reviewed literature on the outbreaks of infectious disease has steadily increased in recent years, but the major pandemics should be compared to find out the similarities and differences. To do so, we provide step by step contents of both diseases.


Keywords: infection control and management, respiratory illness, SARS CoV-2, Spanish Flu

References

Rosenwald, Michael S. "History's deadliest pandemics, from ancient Rome to modern America".

Frost WH. Statistics of influenza morbidity. Public Health Rep. 1920; 35:584–97.

"La Grippe Espagnole de 1918" (in French). Institut Pasteur.

K. Taubenberger, Ann Reid, Amy Krafft et al. Initial Genetic Characterization of the 1998 "Spanish' Influenza Virus. Science. Mar 1997; Vol 275, Issue 5307, pp 1793-1796.

Kendal AP, Noble GR, Skehel JJ, Dowdle WR. Antigenic similarity of influenza A (H1N1) viruses from epidemics in 1977–1978 to "Scandinavian" strains isolated in epidemics of 1950–1951. Virology. 1978; 89:632–6.

Barbara Jester et al. Readiness for Responding to a Severe Pandemic 100 Years After 1918. Am J Epidemiol. July 2018. 187(12): 2596-2602. DOI: 10.1093/aje/kwy165.

P. Johnson and J. Mueller. Updating the accounts: global mortality of the 1918–1920 "Spanish" influenza pandemic. Bull. Hist. Med. 2002. 76(1): 105-115.

Barbara Jester et al. Historical and clinical aspects of the 1918 H1N1 pandemic in the United States. Virology 2019. 527: 32-37.

Barbara Jester et al. 100 Years of Medical Countermeasures and Pandemic Influenza Preparedness. Am J Public Health.

Burnet F, Clark E. Influenza: a survey of the last 50 years in the light of modern work on the virus of epidemic influenza. Melbourne: MacMillan; 1942.

Marks G, Beatty WK. Epidemics. New York: Scribners; 1976.

Rosenau MJ, Last JM. Maxcy-Rosenau preventative medicine and public health. New York: Appleton-Century-Crofts; 1980.

Crosby A. America's forgotten pandemic. Cambridge (UK): Cambridge University Press;1989.

Patterson KD, Pyle GF. The geography and mortality of the 1918 influenza pandemic. Bull Hist Med. 1991;65:4–21.

Johnson NPAS, Mueller J. Updating the accounts: global mortality of the 1918–1920 "Spanish" influenza pandemic. Bull Hist Med. 2002;76:105–15.

Johnson NPAS, Mueller J. Updating the accounts: global mortality of the 1918–1920 "Spanish" influenza pandemic. Bull Hist Med. 2002;76:105–15..018; 108: 1469-1472. Doi:10.2105/AJPH.2018.304586.

Crosby AW. America's forgotten pandemic: the influenza of 1918. Cambridge, UK: Cambridge University Press; 1989 2003.

Patterson KD, Pyle GF. The geography and mortality of the 1918 influenza pandemic. Bull Hist Med. 1991;65:4–21.

Pettit D, Bailie J. A Cruel Wind: Pandemic Flu in America 1918–1920. Murfreesboro, Tennessee: Timberlane Books; 2008.

Influenza 1918 episode (documentary). American Experience. PBS.

Barry, John M. The Great Influenza: The Epic Story of the Greatest Plague in History. Viking Penguin. ISBN 978-0-670-89473-4.

"Mystery pneumonia virus probed in China". BBC News.

Wang C, Horby PW, Hayden FG, Gao GF. A novel coronavirus outbreak of global health concern. Lancet. 2020 Jan 24. pii: S0140-6736(20)30185-9. https://doi.org/10.1016/S0140-6736(20)30185-9.

Perlman S (February 2020). "Another Decade, Another Coronavirus". The New England Journal of Medicine. 382 (8): 760-762. doi:10.1056/NEJMe2001126. PMC 7121143. PMID 31978944.

Cyranoski D (March 2020). "Mystery deepens over the animal source of coronavirus". Nature. 579 (7797): 18–19. Bibcode:2020Natur.579...18C. doi:10.1038/d41586-020-00548-w. PMID 32127703.

https://www.who.int/emergencies/diseases/novel-coronavirus-2019/technical-guidance/naming-the-coronavirus-disease-(COVID-2019)-and-the-virus-that-causes-it

"Naming the coronavirus disease (COVID-19) and the virus that causes it". who.int.

"[The epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases (COVID-19) in China]". Zhonghua Liu Xing Bing Xue Za Zhi = Zhonghua Liuxingbingxue Zazhi (in Chinese). 41 (2): 145–151. doi:10.3760/cma.j.issn.0254-6450.2020.02.003. PMID 32064853.

"WHO Director-General's opening remarks at the media briefing on COVID-19 – 11 March 2020". World Health Organization. 11 March 2020.

"Outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2): increased transmission beyond China – fourth update" (PDF). European Centre for Disease Prevention and Control. 14 February 2020.

Hui DS, I Azhar E, Madani TA, Ntoumi F, Kock R, Dar O, et al. (February 2020). "The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health—The latest 2019 novel coronavirus outbreak in Wuhan, China". Int J Infect Dis. 91: 264–66. doi:10.1016/j.ijid.2020.01.009. PMID 31953166.

"WHO Director-General's opening remarks at the media briefing on COVID-19". World Health Organization (WHO) (Press release). 11 March 2020.

World Health Organization. Coronavirus disease 2019 (COVID-19) Situation Report-89. https://www.who.int/emergencies/diseases/novel-coronavirus-2019/situation-reports/.

Centers for Disease Control and Prevention Types of Influenza Viruses. 2014.

Are we ready for pandemic influenza?Webby RJ, Webster RG Science. 2003 Nov 28; 302(5650):1519-22.

Epidemiology and pathogenesis of influenza. Zambon MC, J Antimicrob Chemother. 1999 Nov; 44 Suppl B:3-9.

Historical perspective--Emergence of influenza A (H1N1) viruses.Zimmer SM, Burke DS, N Engl J Med. 2009 Jul 16; 361(3):279-85.

Zhu N, Zhang D, Wang W, et al. A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med. 2020 Feb 20;382(8):727-33.

Lu R, Zhao X, Li J, et al. Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. Lancet. 2020 Feb 22;395(10224):565-74.

Tang X, Wu C, Li X, et al. On the origin and continuing evolution of SARS-CoV-2. Nat Sci.

Lu R, Zhao X, Li J, et al. Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. Lancet. 2020 Feb 22;395(10224):565-74.

Yan R, Zhang Y, Li Y, et al. Structural basis for the recognition of the SARS-CoV-2 by full-length human ACE2. Science. 2020 Mar 27;367(6485):1444-8.

Chen Y, Guo Y, Pan Y, et al. Structure analysis of the receptor binding of 2019-nCoV. Biochem Biophys Res Commun. 2020 Feb 17

Coutard B, Valle C, de Lamballerie X, et al. The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade. Antiviral Res. 2020 Feb 10; 176:104742.

Zou X, Chen K, Zou J, et al. Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection.

Hanff TC, Harhay MO, Brown TS, et al. Is there an association between COVID-19 mortality and the renin-angiotensin system: a call for epidemiologic investigations. Clin Infect Dis. 2020 Mar 26

Vaughan WT. Influenza: an epidemiological study. Am J Hyg Baltimore. 1921:65–78.

Patterson KD, Pyle GF. The geography and mortality of the 1918 influenza pandemic. Bull Hist Med. 1991; 65:4–21.

Crosby AW. America's forgotten pandemic: the influenza of 1918. Cambridge, UK: Cambridge University Press; 1989 2003.

Pettit D, Bailie J. A Cruel Wind: Pandemic Flu in America 1918–1920. Murfreesboro, Tennessee: Timberlane Books; 2008.

Simonsen L, Clarke MJ, Schonberger LB, Arden NH, Cox NJ, Fukuda K (July 1998). "Pandemic versus epidemic influenza mortality: a pattern of changing age distribution". The Journal of Infectious Diseases. 178 (1): 53–60. CiteSeerX 10.1.1.327.2581. doi:10.1086/515616. JSTOR 30114117. PMID 9652423.

Novel Coronavirus Pneumonia Emergency Response Epidemiology Team. The epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases (COVID-19) in China [in Chinese]. Zhonghua Liu Xing Bing Xue Za Zhi. 2020 Feb 17;41(2):145-51.

Zhan M, Qin Y, Xue X, et al. Death from Covid-19 of 23 health care workers in China. N Engl J Med. 2020 Apr 15.

Dong Y, Mo X, Hu Y, et al. Epidemiological characteristics of 2143 pediatric patients with 2019 coronavirus disease in China. Pediatrics. 2020 Mar 16.

Ludvigsson JF. Systematic review of COVID-19 in children show milder cases and a better prognosis than adults. Acta Paediatr. 2020 Mar 23.

https://www.cdc.gov/flu/pandemic-resources/reconstruction-1918-virus.html#reconstruction.

Zhu N, Zhang D, Wang W, et al. A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med. 2020. https://doi.org/10.1056/NEJMoa2001017.

Wang W, Xu Y, Gao R, et al. Detection of SARS-CoV-2 in Different Types of Clinical Specimens. Jama. 2020.

Sri Santosh T, Parmar R, Anand H, et al. (April 17, 2020) A Review of Salivary Diagnostics and Its Potential Implication in Detection of Covid-19. Cureus 12(4): e7708. doi:10.7759/cureus.7708.

Wu Y, Guo C, Tang L, et al. Prolonged presence of SARS-CoV-2 viral RNA in faecal samples. The Lancet Gastroenterology & Hepatology. 2020.

Chen W, Lan Y, Yuan X, et al. Detectable 2019-nCoV viral RNA in blood is a strong indicator for further clinical severity. Emerging microbes & infections. 2020;9(1):469-473.

"Spanish flu strikes during World War I". 14 January 2010.

"Q & A on COVID-19". European Centre for Disease Prevention and Control.

To KK, Tsang OT, Chik-Yan Yip C, Chan KH, Wu TC, Chan JM, et al. (February 2020). "Consistent detection of 2019 novel coronavirus in saliva". Clinical Infectious Diseases. Oxford University Press: ciaa149. doi:10.1093/cid/ciaa149. PMC 7108139. PMID 32047895.

Loh NW, Tan Y, Taculod J, Gorospe B, Teope AS, Somani J, Tan AY (March 2020). "The impact of high-flow nasal cannula (HFNC) on coughing distance: implications on its use during the novel coronavirus disease outbreak". Canadian Journal of Anaesthesia = Journal Canadien d'Anesthesie. doi:10.1007/s12630-020-01634-3. PMC 7090637. PMID 32189218.

"Coronavirus Disease 2019 (COVID-19) – Transmission". Centers for Disease Control and Prevention.

"Reducing risk of microdroplet infection | NHK WORLD-JAPAN News.

"Modes of transmission of virus causing COVID-19: implications for IPC precaution recommendations". who.int.

Li R, Pei S, Chen B, et al. Substantial undocumented infection facilitates the rapid dissemination of novel coronavirus (SARS-CoV2). Science (New York, NY). 2020.

Li Q, Guan X, Wu P, et al. Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus-Infected Pneumonia. N Engl J Med. 2020; https://doi.org/10.1056/NEJMoa2001316.

"New coronavirus stable for hours on surfaces". National Institutes of Health (NIH).

Holshue ML, DeBolt C, Lindquist S, et al. First case of 2019 novel coronavirus in the United States. N Engl J Med 2020; published online Jan 31. https://doi.org/10.1056/NEJMoa2001191.

Chen H, Guo J, Wan C, et al. Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records. https://doi.org/10.1016/S0140-6736(20)30360-3.

Berglund H, Den s.k. Vol. 15. Allmänna Svenska Läkartidningen; 1918. 'Spanska sjukans' kliniska bild; pp. 1696–701.

Petrén K. Vol. 15. Allmänna Svenska Läkartidningen; 1918. Till influensans, särskilt influensapneumoniernas nosografi och behandling; pp. 1577–600. 1619–30, 1651–69.

Petrén K. Vol. 15. Allmänna Svenska Läkartidningen; 1918. Till influensans, särskilt influensapneumoniernas nosografi och behandling; pp. 1577–600. 1619–30, 1651–69.

The Spanish flu in Uppsala, clinical and epidemiological impact of the influenza pandemic 1918–1919 on a Swedish county,Infection Ecology & Epidemiology. 2014; 4(),. doi: 10.3402/iee.v4.21528.

Guan WJ, Ni ZY, Hu Y, et al. Clinical Characteristics of Coronavirus Disease 2019 in China. The New England journal of medicine. 2020.

Lauer SA, Grantz KH, Bi Q, et al. The Incubation Period of Coronavirus Disease 2019 (COVID-19) From Publicly Reported Confirmed Cases: Estimation and Application. Annals of internal medicine. 2020.

"Symptoms of Novel Coronavirus (2019-nCoV)". US Centers for Disease Control and Prevention. 10 February 2020.

Velavan, T. P.; Meyer, C. G. (March 2020). "The COVID-19 epidemic". Tropical Medicine & International Health. 25 (3): 278–280. doi:10.1111/tmi.13383. PMID 32052514.

"Coronavirus Disease 2019 (COVID-19) – Transmission". Centers for Disease Control and Prevention. 17 March 2020.

Zou L, Ruan F, Huang M, et al. SARS-CoV-2 Viral Load in Upper Respiratory Specimens of Infected Patients. The New England journal of medicine. 2020;382(12):1177-1179.

Liu Y, Yan LM, Wan L, et al. Viral dynamics in mild and severe cases of COVID-19. The Lancet Infectious diseases. 2020.

Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020; pii: S0140-6736(20)30183-5. https://doi.org/10.1016/S0140-6736(20)30183-5.

"Symptoms of Novel Coronavirus (2019-nCoV)". US Centers for Disease Control and Prevention. 10 February 2020.

Chen N, Zhou M, Dong X, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet (London, England). 2020;395(10223):507-513.

Wu C, Chen X, Cai Y, et al. Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China. JAMA Intern Med. 2020.

Yang X, Yu Y, Xu J, et al. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study. The Lancet Respiratory medicine. 2020.

Zhou F, Yu T, Du R, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet (London, England). 2020.

Pan L, Mu M, Ren HG, et al. Clinical characteristics of COVID-19 patients with digestive symptoms in Hubei, China: a descriptive, cross-sectional, multicenter study. Am J Gastroenterol. 2020.

Giacomelli A, Pezzati L, Conti F, et al. Self-reported olfactory and taste disorders in SARS-CoV-2 patients: a cross-sectional study. Clinical Infectious Diseases. 2020.

Iacobucci G (March 2020). "Sixty seconds on anosmia". BMJ. 368: m1202. doi:10.1136/bmj.m1202. PMID 32209546.

Vito Fanelli, Marco Fiorentino, et al. Acute kidney injury in SARS-CoV-2 infected patients,Critical Care volume 24, Article number: 155 (2020),bmc.

Ronco C, Navalesi P, Vincent JL. Coronavirus epidemic: preparing for extracorporeal organ support in intensive care. Lancet Respir Med 2020; 8(3): 240–241. doi: https://doi.org/10.1016/S2213-2600(20)30060-6.

Barry JM (January 2004). "The site of origin of the 1918 influenza pandemic and its public health implications". Journal of Translational Medicine. 2 (1): 3. doi:10.1186/1479-5876-2-3. PMC 340389. PMID 14733617.

Patterson KD, Pyle GF (1991). "The geography and mortality of the 1918 influenza pandemic". Bulletin of the History of Medicine. 65 (1): 4–21. PMID 2021692.

Knobler S, Mack A, Mahmoud A, Lemon S, eds. (2005). "1: The Story of Influenza". The Threat of Pandemic Influenza: Are We Ready? Workshop Summary (2005). Washington, DC: The National Academies Press. pp. 60–61.

Morris, Denise E.; Cleary, David W.; Clarke, Stuart C. (2017). "Secondary Bacterial Infections Associated with Influenza Pandemics". Frontiers in Microbiology. 8. doi:10.3389/fmicb.2017.01041. ISSN 1664-302X.

Vilensky JA, Foley P, Gilman S (August 2007). "Children and encephalitis lethargica: a historical review". Pediatric Neurology. 37 (2): 79–84. doi:10.1016/j.pediatrneurol.2007.04.012. PMID 17675021

Novel Coronavirus Pneumonia Emergency Response Epidemiology T. [The epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases (COVID-19) in China]. Zhonghua Liu Xing Bing Xue Za Zhi. 2020;41(2):145-151.

Madjid M, Safavi-Naeini P, Solomon SD, et al. Potential effects of coronaviruses on the cardiovascular system: a review. JAMA Cardiol. 2020 Mar 27.

Ye Q, Wang B, Mao J. Cytokine storm in COVID-19 and treatment. J Infect. 2020 Apr 10

Sun P, Qie S, Liu Z, et al. Clinical characteristics of 50466 hospitalized patients with 2019-nCoV infection. J Med Virol. 2020 Feb 28

Dong Y, Mo X, Hu Y, et al. Epidemiological characteristics of 2143 pediatric patients with 2019 coronavirus disease in China. Pediatrics. 2020 Mar 16.

Xu L, Liu J, Lu M, et al. Liver injury during highly pathogenic human coronavirus infections. Liver Int. 2020 Mar 14.

Ranucci M, Ballotta A, Di Dedda U, et al. The procoagulant pattern of patients with COVID-19 acute respiratory distress syndrome. J Thromb Haemost. 2020 Apr 17

Klok FA, Kruip MJHA, van der Meer NJM, et al. Incidence of thrombotic complications in critically ill ICU patients with COVID-19. Thromb Res. 2020 Apr 10.

Oxley TJ, Mocco J, Majidi S, et al. Large-vessel stroke as a presenting feature of Covid-19 in the young. N Engl J Med. 2020 Apr 28.

Zhao H, Shen D, Zhou H, et al. Guillain-Barré syndrome associated with SARS-CoV-2 infection: causality or coincidence? Lancet Neurol. 2020 May;19(5):383-4.

Rodriguez-Morales AJ, Cardona-Ospina JA, Gutiérrez-Ocampo E, et al. Clinical, laboratory, and imaging features of COVID-19: a systematic review and meta-analysis. Travel Med Infect Dis. 2020 Mar 13:101623.

Chen N, Zhou M, Dong X, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet. 2020 Feb 15;395(10223):507-13.

Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020 Feb 15;395(10223):497-506.

Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020 Feb 15;395(10223):497-506.

Zou L, Ruan F, Huang M, et al. SARS-CoV-2 Viral Load in Upper Respiratory Specimens of Infected Patients. The New England journal of medicine. 2020;382(12):1177-1179.

Guo L, Ren L, Yang S, et al. Profiling Early Humoral Response to Diagnose Novel Coronavirus Disease (COVID-19). Clinical infectious diseases: an official publication of the Infectious Diseases Society of America. 2020.

Beach, Brian; Ferrie, Joseph P.; Saavedra, Martin H. (2018). "Fetal shock or selection? The 1918 influenza pandemic and human capital development". nber.org. doi:10.3386/w24725.

Almond, Douglas "Is the 1918 Influenza Pandemic Over? Long‐Term Effects of In Utero Influenza Exposure in the Post‐1940 U.S. Population". Journal of Political Economy. 114 (4): 672–712. doi:10.1086/507154. ISSN 0022-3808.

"Here Comes the Coronavirus Pandemic: Now, after many fire drills, the world may be facing a real fire". Editorial. The New York Times. 29 February 2020.

"COVID-19 Educational Disruption and Response". UNESCO. 4 March 2020.

Rico-AvelloC. Historia de la sanidad Española (1900–1935),1969 Madrid Gimenez.

Echeverri B. La gripe española: la pandemia de 1918–1919, Coleccion Monografias (132), 1993 Madrid Centro de Investigaciones Sociologicas.

Bertran JL, Historia de las epidemias en España y sus colonias (1348–1919), 2006MadridLa Esfera de los Libros.

Spinney L (29 March 2020). "Coronavirus vaccine: when will it be ready?". The Guardian. ISSN 0261-3077.

"Prevention & Treatment". US Centers for Disease Control and Prevention. 15 February 2020. Archived from the original on 15 December 2019.

"Coronavirus disease (COVID-19) advice for the public: When and how to use masks". World Health Organization.

Lu CW, Liu XF, Jia ZF. 2019-nCoV transmission through the ocular surface must not be ignored. Lancet. 2020; pii: S0140-6736(20)30313-5. https://doi.org/10.1016/S0140-6736(20)30313-5.

Thordarson, Pall (12 March 2020). "The science of soap – here's how it kills the coronavirus | Pall Thordarson". The Guardian. ISSN 0261-3077.

Kampf G, Todt D, Pfaender S, Steinmann E (March 2020). "Persistence of coronaviruses on inanimate surfaces and their inactivation with biocidal agents". The Journal of Hospital Infection. 104 (3): 246–251.

"Coronavirus Disease 2019 (COVID-19)". US Centers for Disease Control and Prevention.

"Coronavirus disease (COVID-19) advice for the public: When and how to use masks". World Health Organization.

"Coronavirus Disease 2019 (COVID-19): If You Have Animals". cdc.gov.

Sandee LaMotte, Lions, tigers and house cats: You won't catch coronavirus from felines, experts say, 6 April 2020, CNN.

suppl 1–32. Vol. 21. Allmänna Svenska Läkartidningen; 1924. Influensakommitens rapport; p. 9.

Hatchett RJ, Mecher CE, Lipsitch M. Public health interventions and epidemic intensity during the 1918 influenza pandemic. Proc Natl Acad Sci U S A. 2007; 104:7582–7.

Grönstedt K. Allmänna Svenska läkartidningen; 1919. Spanska sjukans behandling; pp. 19–21.

Bjerner B. Allmänna Svenska Läkartidningen; 1919. Antidifteri serum mot influenza; pp. 103–105.

Engelsson H. Allmänna Svenska Läkartidningen; 1919. Neosalvarsan och kvicksilver någon skyddande effekt mot influenza? pp. 362–364.

Wållgren C. Spanska sjukan vid sahlgrenska sjukhuset. [The Spanish flu at the Sahlgrenska Hospital]. Hygiea. 1920; 82:257–70.

Starko KM. Salicylates and pandemic influenza mortality, 1918–1919 pharmacology, pathology, and historic evidence. Clin Infect Dis. 2009; 49:1405–10.

"Q&A on coronaviruses". World Health Organization. 11 February 2020.

A randomized, open-label, blank-controlled trial for the efficacy and safety of lopinavir-ritonavir and interferon-alpha 2b in hospitalization patients with novel coronavirus infection. Available from www.chictr.org.cn/showprojen.aspx?proj=48684.

Bin Cao, M.D., Yeming Wang, M.D., Danning Wen, M.D., et al.A trial of Lopinavir-Ritonavir in Adults Hospitalized with Severe Covid-19. N Engl J Med. DOI: 10.1056/NEJMoa2001282.

Holshue ML, DeBolt C, Lindquist S, et al. First case of 2019 novel coronavirus in the United States. N Engl J Med 2020; published online Jan 31. https://doi.org/10.1056/NEJMoa2001191.

Kui L, Fang YY, Deng Y, et al. Clinical characteristics of novel coronavirus cases in tertiary hospitals in Hubei Province. Chin Med J (Engl). 2020. https://doi.org/10.1097/CM9.0000000000000744.

Richardson P, Griffin I, Tucker C, et al. Baricitinib as potential treatment for 2019-nCoV acute respiratory disease. Lancet. 2020 Feb 4. pii: S0140-6736(20)30304-4. https://doi.org/10.1016/S0140-6736(20)30304-4.

"Caring for Yourself at Home". Centers for Disease Control and Prevention. 11 February 2020.

Paton N.I., Lee L., Xu Y., Ooi E.E., Cheung Y.B., Archuleta S. Chloroquine for influenza prevention: a randomised, double-blind, placebo controlled trial. Lancet Infect Dis. 2011 Sep;11(9):677–683.

Vigerust D.J., McCullers J.A. Chloroquine is effective against influenza A virus in vitro but not in vivo. Influenza Other Respir Viruses. 2007; 1:189–192.

Wang M., Cao R., Zhang L., Yang X., Liu J., Xu M. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 2020.

Colson P., Rolain J.M., Lagier J.C., Brouqui P., Raoult D. Chloroquine and hydroxychloroquine as available weapons to fight COVID-19. Int J Antimicrob Agents. 2020 Mar 4:105932.

Ahn JY, Sohn Y, Lee SH, et al. Use of Convalescent Plasma Therapy in Two COVID-19 Patients with Acute Respiratory Distress Syndrome in Korea. J Korean Med Sci. 2020 Apr 13;35(14):e149. doi: 10.3346/jkms.2020.35.e149.

Chen L, Xiong J, Bao L, Shi Y. Convalescent plasma as a potential therapy for COVID-19. Lancet Infect Dis. 2020;20(4):398–400.

Spinney L, "Coronavirus vaccine: when will it be ready?". The Guardian. ISSN 0261-3077.

Huaxia. WHO says vaccines against novel coronavirus 18 months away, pushes global research. 2020. Xinhuanet, Feb 12, 2020. http://www.xinhuanet.com/english/2020-02/12/c_138777886.htm.

"WHO Director-General's opening remarks at the media briefing on COVID-19 – 11 March 2020". World Health Organization. 11 March 2020.

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How to Cite
Saulat, A., & Jafri, A. N. (2021). A Narration: 20th v/s 21st Century: Pandemic v/s Another Pandemic: Virus v/s Another Virus (Spanish Flu V/S COVID-19). European Journal of Medical and Health Sciences, 3(1), 1-8. https://doi.org/10.24018/ejmed.2021.3.1.594