In 1954 , two independent research teams, one consisting of Andrew F. Huxley and Rolf Niedergerke from the University of Cambridge, and the other consisting of Hugh Huxley and Jean Hanson from the Massachusetts Institute of Technology proposed the theory of skeletal muscle contraction . They used electron microscopy to study the details of muscle filaments. The structure was studied in detail by then, but the mechanism of skeletal muscle contraction was not defined. Based on various assumptions about the actin and myosin filaments of muscle, later they postulated a theory called “sliding filament theory”. When this theory is scrutinized in detail, I find that there are a lot of defects in this theory, which I have pointed out and I have made an attempt to postulate a different mechanism for the skeletal muscle contraction.
John M Squire Muscle contraction: Sliding filament history, sarcomere dynamics and the two Huxleys Glob Cardiol Sci Pract. 2016 Jun 30; 2016(2): e201611. Published online 2016 Jun 30. doi: 10.21542/gcsp.2016.11.
John E. Hall, Guyton and Hall Textbook of Medical Physiology.
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