Platelet-Rich Plasma in the Management of Chronic Endometritis Treatment in Women with Reproductive Health Disorders


  •   V. O Sklyarova

  •   K. L. Shatylovich

  •   A. L. Filipyuk

  •   P. O. Sklyarov

  •   R. A. Chajkivskyj


Background: Chronic endometritis (CE) is one of aggressive factor of infertility and reproductive losses.

Objective: We aimed to assess the effectiveness of using platelet-rich plasma (PRP) treatment of chronic endometritis (CE) treatment in women with infertility (PI) and recurrent pregnancy losses (RPL).

Material and methods: In this non-randomized clinical trial, women aged 22-45 years with CE diagnosed by positive CD 138 between February 2017 and December 2019 were included. Were investigated 65 women - 30 patients with RPL and 35 women with PI and unsuccessful attempts at IVF. PRP therapy was performed paracervical ( 6 ml) and intrauterus ( 1,5 ml) once a week for 4 -8 weeks. Control of the treatment of CE was performed by endometrial biopsy pipelines 15-20 days after the last PRP.

Results: After carrying out 4 procedures of combined paracervical and intrauterine PRP, CE was cured in 70-77% of women (p <0.05); after 8 procedures - 97% (p <0.01).

Conclusions: Combined intrauterine and paracervical PRP therapy is an effective treatment for CE in women with PI and RPL.

Keywords: chronical endometritis, Platelet-rich Plasma, infertility, recurrent pregnancy loss


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How to Cite
Sklyarova, V. O., Shatylovich, K. L., Filipyuk, A. L., Sklyarov, P. O., & Chajkivskyj, R. A. (2020). Platelet-Rich Plasma in the Management of Chronic Endometritis Treatment in Women with Reproductive Health Disorders. European Journal of Medical and Health Sciences, 2(6).