Neurologic Manifestations of SARS-CoV-2, the Virus that Causes COVID-19


  •   Hassan Naji


Coronaviruses have been associated with many outbreaks in the past and the recent pandemic caused by SARS-CoV-2 has spread around the globe due to its high transmission rate. SARS-CoV-2 has reported to be associated with respiratory and cardiac complications, but recent case series and case reports of COVID-19 patients suggest that it is also associated with neurological manifestations. The most commonly observed neurological manifestation are headache, anomia, ageusia, dizziness, delirium and the complications include Guillain-Barre syndrome (GBS), acute encephalitis, acute myelitis, and cerebrovascular disorders. The pathways leading to neuronal damage are the retrograde neuronal and hematogenous pathway. This paper is aimed to explain the neurological manifestations associated with COVID-19 patients and the possible pathophysiological mechanisms of neuronal invasion.

Keywords: 2019-nCoV, SARS-CoV-2, Coronavirus, Novel coronavirus, COVID-19, MERS-CoV, SARS-CoV, Receptor-binding domain, ACE2 receptors, Central nervous system, Neurologic manifestation, Hypogeusia, Hyposmia, Neuralgia, Impaired consciousness, Acute cerebral diseases, Acute hemorrhagic necrotizing encephalopathy, Transverse myelitis and encephalitis, Epilepsy, Guillain-Barre syndrome, Ataxia, Skeletal muscle injury


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How to Cite
Naji, H. (2020). Neurologic Manifestations of SARS-CoV-2, the Virus that Causes COVID-19. European Journal of Medical and Health Sciences, 2(6).