α-Glucosidase Inhibitory and Antiradical Properties of Acacia macrostachya

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  •   Hamidou Têeda Ganamé

  •   Yssouf Karanga

  •   Ousmane Ilboudo

  •   Wende-Konté Hazael Conania Nikiema

  •   Richard Wamtinga Sawadogo

  •   Issa Tapsoba

Abstract

In this work, the anti-diabetic activity of three extracts of Acacia macrostachya was investigated by following the inhibitory effect of these extracts on -glucosidase using the in vitro model. The antiradical activity of these extracts was also determined. Methanol extracts of root and stem barks showed a very significant inhibitory effect against the enzyme activity of -glucosidase with IC50 2.487 ± 0.441 µg/mL and 1.650 ± 0.229 µg/mL respectively. For antiradical activity, the same extracts presented the highest scavenging of the radical DPPH with IC50 values of 9.307 ± 0.262 µg/mL and 5.242 ± 0.068 µg/mL respectively. With the cationic radical ABTS●+, IC50 varied from 45.049 ± 0.730 µg/mL for methanolic root barks extract to 14.136 ± 0.161 µg/mL for methanolic extract from stem barks. Thus, the methanol extracts of the root and stem barks of Acacia macrostachya possess compounds with very interesting anti-diabetic and antiradical properties and could justify its traditional use.


Keywords: Acacia macrostachya, Antiradical Activity, Diabetes, α-Glucosidase

References

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How to Cite
Ganamé, H. T., Karanga, Y., Ilboudo, O., Nikiema, W.-K. H. C., Sawadogo, R. W., & Tapsoba, I. (2020). α-Glucosidase Inhibitory and Antiradical Properties of Acacia macrostachya. European Journal of Medical and Health Sciences, 2(5). https://doi.org/10.24018/ejmed.2020.2.5.465