Role Of Vitamin K Therapy In Prevention Of Vascular Calcification In Chronic Kidney Disease

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  •   Mohamed Farouk Ibrahim Mosa

  •   Ahmed Kamal Harfoosh

Abstract

Introduction: Matrix Gla protein (MGP) is a central calcification inhibitor of vascular wall. The biological activation of the calcification-inhibitory protein MGP can be achieved by simple administration of oral vitamin K.


Aim: The study was conducted to assess the effect of vitamin k supplementation on vascular calcification and to evaluate its effect on MGA in hemodialysis patients.


Materials and Methods: Forty adult patients with end stage renal disease (ESRD) on regular hemodialysis sessions, thrice weekly, were enrolled in the study and were randomly assigned into two groups. Vitamin K group consisted of 20 patients were given oral vitamin K at 10 mg after each session of dialysis for a duration of one year. No-Vitamin K group included 20 patients didn’t receive vitamin K. All patients were subjected to the following: Matrix Gla protein (MGP), in addition to, plain digital abdominal x-ray and doppler ultrasound.


Results: After one-year of vitamin K supplementation, a significant increase in MGP levels in Vitamin K group (75.7±26 ng/mL) were noticed. There were no significant changes in CIMT and AACS in Vitamin K group after vitamin K supplementation in compared to their baseline levels, while the CIMT and AACS were significantly increased in No-Vitamin K group in compared to their baseline levels.


Conclusion: Vitamin K supplementation could not stop vascular calcifications but significantly attenuate their progression.


Keywords: CKD, Vascular calcification, Vitamin K supplementation

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How to Cite
Ibrahim Mosa, M., & Harfoosh, A. (2020). Role Of Vitamin K Therapy In Prevention Of Vascular Calcification In Chronic Kidney Disease. European Journal of Medical and Health Sciences, 2(4). https://doi.org/10.24018/ejmed.2020.2.4.360