Cardiovascular Complications Associated with COVID-19 Infection

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  •   Hassan S. Naji

Abstract

COVID-19 has spread worldwide and caused pneumonia-like illness similar to that caused by SARS-CoV and MERS-CoV. Apart from lung injury, coronaviruses cause severe cardiovascular disorders. Studies have confirmed that COVID-19 uses angiotensin-converting enzyme 2 (ACE2) receptor to enter the host cell similar to SARS-CoV. ACE2 receptors are found in various body organs including lungs, heart in kidneys. The most common complication observed are acute respiratory distress syndrome, acute cardiac injury and cardiovascular disorders including myocarditis, cardiac arrythmias and myocardial infarction. It can also cause acute and chronic cardiovascular diseases. Almost 20% of patients progress to severe condition. Patients with underlying cardiovascular disorders have poor prognosis. It is believed that ACEI/ARBS can alleviate the cardiovascular problems in COVID-19 patients. Hence, the risk factors for cardiovascular disease and complications should be carefully considered.


Keywords: SARS-CoV-2, 2019 Novel Coronavirus, COVID-19, SARS-CoV, MERS-CoV, Coronaviridae, Cardiovascular diseases, ACE1, ACE2, Diabetes, Hypertension, Hypotension, Bradycardia, Arrythmias, Myocarditis, Acute cardiac injury, Shock, Sudden cardiac death, Myocardial infarction (MI), Epidemiology of COVID-19, Cardiovascular complications, Cardiovascular comorbidities, Myocardial injury, Heart failure, Renal failure, Liver failure

References

Chen L., Li X., Chen M., Feng Y., & Xiong C. (2020). The ACE2 expression in human heart indicates new potential mechanism of heart injury among patients infected with SARS-CoV-2. Cardiovascular Research, 2–5. https://doi.org/10.1093/cvr/cvaa078.

Chen N., Zhou M., Dong X., Qu J., Gong F., Han Y., Yu T. (2020). Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan , China : a descriptive study. The Lancet, 395(10223), 507–513. https://doi.org/10.1016/S0140-6736(20)30211-7.

Dhanachandra Singh K., & Karnik S. S. (2017). Angiotensin Receptors: Structure, Function, Signaling and Clinical Applications. Journal of Cell Signaling. https://doi.org/10.4172/2576-1471.1000111

Guan W., Ni Z., Hu, Y., Liang W., Ou C., He J., Zhong N. (2020). Clinical characteristics of 2019 novel coronavirus infection in China. MedRxiv. https://doi.org/10.1101/2020.02.06.20020974.

Guo J., Huang Z., Lin L., & Lv J. (2020). Coronavirus Disease 2019 (COVID‐19) and Cardiovascular Disease: A Viewpoint on the Potential Influence of Angiotensin‐Converting Enzyme Inhibitors/Angiotensin Receptor Blockers on Onset and Severity of Severe Acute Respiratory Syndrome Coronavirus 2 Infec. Journal of the American Heart Association, 9(7), 1–5. https://doi.org/10.1161/jaha.120.016219.

Huang C., Wang Y., Li X., Ren L., Zhao J., Hu Y., Gu X. (2020a). Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. The Lancet, 497–506. https://doi.org/10.1016/S0140-6736(20)30183-5.

Huang C., Wang Y., Li X., Ren L., Zhao J., Hu Y., Gu X. (2020b). Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. The Lancet, 497–506. https://doi.org/10.1016/S0140-6736(20)30183-5.

Madjid M., Safavi-Naeini P., Solomon S. D., & Vardeny O. (2020). Potential Effects of Coronaviruses on the Cardiovascular System: A Review. JAMA Cardiology, 10, 1–10. https://doi.org/10.1001/jamacardio.2020.1286.

Naji H. (2020). Cytokine Storm of SARS-CoV-2, The Virus That Causes COVID-19. European Journa of Medical and Health Sciences. http://dx.doi.org/10.24018/ejmed.2020.2.3.245.

Schouten L. R., van Kaam A. H., Kohse F., Veltkamp F., Bos L. D., de Beer F. M., Verboom D. M. (2019). Age-dependent differences in pulmonary host responses in ARDS: a prospective observational cohort study. Annals of Intensive Care. https://doi.org/10.1186/s13613-019-0529-4.

Wan Y., Shang J., Graham R., Baric R. S., & Li F. (2020). Receptor recognition by novel coronavirus from Wuhan: An analysis based on decade-long structural studies of SARS. Journal of Virology. https://doi.org/10.1128/jvi.00127-20

Wang D., Hu B., Hu C., Zhu F., Liu X., Zhang, J., Peng Z. (2020). Clinical Characteristics of 138 Hospitalized Patients with 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China. JAMA - Journal of the American Medical Association. https://doi.org/10.1001/jama.2020.1585.

Xiong T.-Y., Redwood S., Prendergast B., & Chen M. (2020). Coronaviruses and the cardiovascular system: acute and long-term implications. European Heart Journal. https://doi.org/10.1093/eurheartj/ehaa231.

Yang X., Yu Y., Xu J., Shu H., Xia J., Liu H., Shang Y. (2020). Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study. The Lancet Respiratory Medicine. https://doi.org/10.1016/S2213-2600(20)30079-5.

Zheng Y. Y., Ma Y. T., Zhang J. Y., & Xie X. (2020). COVID-19 and the cardiovascular system. Nature Reviews Cardiology. https://doi.org/10.1038/s41569-020-0360-5.

Zhou F., Yu T., Du R., Fan G., Liu Y., Liu Z.,Cao B. (2020). Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. The Lancet. https://doi.org/10.1016/S0140-6736(20)30566-3.

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How to Cite
Naji, H. (2020). Cardiovascular Complications Associated with COVID-19 Infection. European Journal of Medical and Health Sciences, 2(4). https://doi.org/10.24018/ejmed.2020.2.4.343