Objective: To identify the incidence of seizures within 48 hours of COVID-19 vaccination in PWE
Methods: This is a retrospective cross-sectional observational study performed at two Northern Virginia neurology clinics. PWE that had been vaccinated against COVID-19 were surveyed to report occurrence of a seizure within 48 hours of COVID-19 vaccination and the presence of additional triggers surrounding the seizure.
Results: Of the 189 patients included in the analysis, 13 (7%) reported a seizure within 48 hours of vaccination. Of the 13 participants with reported seizures, 10 identified possible triggers present at the time of their seizure. Additionally, patients with intractable epilepsy were found to have a non-statistically significant (p = 0.16) increased risk of seizure (odds ratio = 2.2) within 48 hours of vaccination.
Conclusion: The results show a low incidence of seizure within 48 hours of receiving a COVID-19 vaccination in this cohort of PWE. Those that reported seizures had additional provoking factors present that may have triggered the seizure. For patients with intractable epilepsy it appears they may have some increased risk of breakthrough seizures within 48 hours of vaccination. It is recommended that clinicians counsel their epilepsy patients, especially those with an intractable diagnosis, to mitigate potential seizure triggers prior to vaccine administration. Further research is recommended to observe for long term effects if present and to control for provoking seizure factors/triggers.
Keezer MR, Sisodiya SM, Sander JW. Comorbidities of epilepsy: current concepts and future perspectives. Lancet Neurol. 2016; 15(1): 106-115. DOI: https://doi.org/10.1016/S1474-4422(15)00225-2
Cabezudo-García P, Ciano-Petersen NL, Mena-Vázquez N, Pons-Pons G, Castro-Sánchez MV, Serrano-Castro PJ. Incidence and case fatality rate of COVID-19 in patients with active epilepsy. Neurology. 2020; 95(10): e1417-e1425. DOI: https://doi.org/10.1212/WNL.0000000000010033
Vergara RJD, Sarmiento PJD, Lagman JDN. Building public trust: a response to COVID-19 vaccine hesitancy predicament. J Public Health (Oxf). 2021; 43(2): e291-e292. DOI: https://doi.org/10.1093/pubmed/fdaa282
Puteikis K, Mameniškienė R. Factors Associated with COVID-19 Vaccine Hesitancy among People with Epilepsy in Lithuania. Int J Environ Res Public Health. 2021; 18(8): 4374. DOI: https://doi.org/10.3390/ijerph18084374
Lu L, Xiong W, Mu J, Zhang Q, Zhang H, Zou L, et al. The potential neurological effect of the COVID‐19 vaccines: a review. Acta Neurologica Scandinavica. 2021; 144(1): 3-12. DOI: https://doi.org/10.1111/ane.13417
von Wrede R, Pukropski J, Moskau-Hartmann S, Surges R, Baumgartner T. COVID-19 vaccination in patients with epilepsy: First experiences in a German tertiary epilepsy center. Epilepsy Behav. 2021; 122: 108160. DOI: https://doi.org/10.1016/j.yebeh.2021.108160
Massoud F, Ahmad SF, Hassan AM, Alexander KJ, Al–Hashel J, Arabi M. Safety and tolerability of the novel 2019 coronavirus disease (COVID-19) vaccines among people with epilepsy (PwE): A cross-sectional study. Seizure. 2021; 92: 2-9. DOI: https://doi.org/10.1016/j.seizure.2021.08.001
Gee J, Marquez P, Su J, Calvert GM, Liu R, Myers T, et al. First Month of COVID-19 Vaccine Safety Monitoring — United States, December 14, 2020–January 13, 2021. MMWR Morb Mortal Wkly Rep. 2021; 70(8): 283-288. DOI: https://doi.org/10.15585/mmwr.mm7008e3
Callaghan B, Schlesinger M, Rodemer W, Pollard J, Hesdorffer D, Allen Hauser W, et al. Remission and relapse in a drug-resistant epilepsy population followed prospectively. Epilepsia. 2011; 52(3): 619-626. DOI: https://doi.org/10.1111/j.1528-1167.2010.02929.x
Epilepsy. [Internet] [cited 2021 October 25] Available from: https://www.who.int/news-room/fact-sheets/detail/epilepsy
Han X, Khaja F. Demographic Reports 2020 County of Fairfax Virginia. [Internet] Available from: https://www.fairfaxcounty.gov/demographics/sites/demographics/files/assets/demographicreports/fullrpt2020.pdf