Effect of the Perioperative Intravenous Lidocaine Infusion of 1.25 mg/kgBW/H on the Bowel Sound Recovery and Pain Intensity after Laparoscopic Cholecystectomy


  •   Syafri Kamsul Arif

  •   Yongki Rawung

  •   A. Muh Takdir Musba

  •   A. Husni Tanra


The purpose of this research is to assess the effect of perioperative intravenous lidocaine infusion of 1.25mg/kgBW/H on the bowel sounds recovery and pain intensity after laparoscopy cholecystectomy. The research used the experimental method, i.e. 42 patients who met the inclusive criteria and who would undergo laparoscopic cholecystectomy surgery under the general anesthesia, using the randomized double blind technique, and then were divided into two groups. The Treatment Group (KL, n = 21) received perioperative intravenous lidocaine infusion of 1.25 mg/kgB/H, while the control group (KN, n = 21) received the perioperative infusion of placebo of 0.9 NaCl. After the surgery, the assessments of the bowel sounds recovery time, the NRS scores at 2h, 6h, 12h, and 24h and the fentanyl requirement within 24 hours with PCA were conducted. The data were analyzed using the Chi square test, independent-t test, and Mann-Whitney test with p<0.05 to reveal the statistical significance. The research results indicated that the time of the bowel sounds recovery in KL group was 147.14 ± 24.928 minutes, faster than in KN group it was 322.86 ± 34.079 minutes (p=0.000). The postoperative NRS score at 2h and 6h in KL group was lower than the KN group with p=0,000, but there was no significant difference in the postoperative NRS score at 12h and 24h in both groups (p>0.05). The postoperative fentanyl requirement was lower in KL group (114.29 ± 31.196) mcg compared to the KN group (258.33 ± 27.764) mcg with p=0.000. The Perioperative intravenous lidocaine infusion of 1.25 mg/kgBB/h could speed up the bowel sounds recovery and reduce the pain intensity after laparoscopic cholecystectomy. 

Keywords: Keywords: bowel sounds recovery, laparoscopic cholecystectomy, lidocaine, pain intensity


Baral et al. (2010). Perioperative Intravenous Lidocaine Infusion on Postoperative Pain Relief in Patients Undergoing Upper Abdominal Surgery. Nepal Med Coll J. 12(4): 215-20.

Cho et al. (2014). Effect of Perioperative Infusion of Lidokaine vs. Dexmedetomidine on Reduced Consumption of Postoperative Analgesics After Laparascopic Cholecystectomy. Anesth Pain Med. 9: 185-92.

Choi et al. (2012). Effect of Intraoperative Lidocaine on Anesthetic Consumption, and Bowel Function, Pain Intensity, Analgesic Consumption and Hospital Stay After Breast Surgery. Korean J Anesthesiol. 62(5): 429-34.

Deeb et al. (2013). The Effects of Intravenous Lidocaine Infusion on Hospital Stay After Major Abdomen Pediatric Surgery: A Randomized Double-Blinded Study. EgJA. 29: 225-30.

Grady et al. (2012). Effect of Intraoperative Intravenous Lidocaine on Postoperative Pain and Return of Bowel Function After Laparascopic Abdomen Gynecologic Procedures. AANA Journal. 80(4): 282-88.

Ivan. (2015). Pengaruh Pemberian Lidokain Intravena dalam Mengurangi Kebutuhan Opioid pada Penanganan Nyeri Pascabedah Laparatomi Histerektomi. [Tesis]. Makassar: Universitas Hasanuddin.

Khan et al. (2016). An Estimation for an Appropriate End Time for an Intraoperative Intravenous Lidocaine Infusion in Bowel Surgery: a Comparative Meta-Analysis. JCA. 28: 95-104.

Kranke et al. (2015). Continous Intravenous Perioperative Lidocaine Infusion for Postoperative Pain and Recovery. Cochrane Database of Systematic Review. Issue 7. Art. No: CD009642. DOI: 10.1002/14651858.CD009642.pub2.

Lauretti. (2008). Mechanisms of Analgesia of Intravenous Lidocaine. Rev Bras Anestesiol. 58(3): 280-6.

Lauwick et al. (2008). Intraoperative Infusion of Lidocaine Reduces Postoperative Fentanyl Requirements in Patients Undergoing Laparoscopic Cholecystectomy. Can J Anesth. 55 (11): 754-60.

Martin et al. (2008). Lack of Impact of Intravenous Lidocaine on Analgesia, Functional Recovery, and Nociceptive Pain Threshold After Total Hip Arthroplasty. Anesthesiology. 109(1): 118-23.

Stoelting. (2015). Local Anesthetics. In: Pharmacology and Phisiology in Anesthetic Practice. 3rd ed. USA: Lippincot-Raven.

Ventham et al. (2015). Efficacy of Intravenous Lidocaine for Postoperative Analgesia Following Laparascopic Surgery: A Meta-Analysis. World J Surg. 39(9): 2220-34. DOI: 10.1007/s00268-015-3105-6.

Yang et al. (2013). Efficacy of Intraperitoneal and Intravenous Lidokaine on Pain Relief After Laparascopic Cholecystectomy. Journal of International Medical Research. 1-13.


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How to Cite
Arif, S., Rawung, Y., Musba, A. M., & Tanra, A. (2019). Effect of the Perioperative Intravenous Lidocaine Infusion of 1.25 mg/kgBW/H on the Bowel Sound Recovery and Pain Intensity after Laparoscopic Cholecystectomy. European Journal of Medical and Health Sciences, 1(1). https://doi.org/10.24018/ejmed.2019.1.1.15