The best way to deliver a drug in pursuit of maximum potential is to deliver it with maximal bioavailability. There are many options in delivering a drug, but each way reduces the drug's bioavailability differently. For treating localized discomfort, the transdermal approach or the topical approach is considered to be an advantageous one mainly because of its rapid localized action and the fewest side effects associated with this route. Drug delivery through topicals is an easy-to-reach approach and, in most cases, bypasses the first-pass metabolism. However, under certain conditions, the drug either needs to be delivered in its unaffected, concentrated form or needs to be delivered deeper into the dermal layers of the skin with immediate effect. This paper will review and suggest all those possible ways through which topical drug delivery can be universally enhanced in rate, effectiveness, and efficiency. Specialized ultrasound waves and sub-spectrum far-infrared heat help accelerate and deliver topical ingredients to the site of action. Making this the basis of our argument, we shall see in detail why they help achieve the desired results and why both these methods should be adapted in a combined approach to deliver the drug to the precise site of action through the topical or transdermal approach. Furthermore, Cannabidiol (CBD) is a model drug in this paper due to its faster absorption rate and outnumbered measurable benefits.
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