High Maternal Cortisol Serum Levels as A Risk Factor for Preterm Labor

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  •   Tjokorda Gde Agung Suwardewa

  •   Ketut Surya Negara

  •   I Gede Mega Putra

  •   I Wayan Artana Putra

  •   Evert Solomon Pangkahila

  •   I Gede Bagus Garjita Maesa Putra

Abstract

Preterm delivery is the leading cause of death for children under 5 years of age worldwide. Preterm delivery is one of the significant factors causing neonatal death due to complications associated with preterm birth. Complications of preterm delivery account for about 16% of all deaths in children under 5 years, and 35% of total deaths of newborns. There are several broad outlines of factors associated with preterm labor, including stress, inflammation or infection, overdistention of the uterus and the hypothalamic-pituitary-adrenal axis. Several studies show the role of cortisol caused by these factors. This study aimed to assess the relationship of maternal serum cortisol levels with the risk of preterm delivery. This study used a case-control design conducted at Sanglah Hospital, Denpasar from May to August 2021. A sample of 50 women was obtained which was divided into case groups and control groups. Serum cortisol examination used a 3 mL blood sample which was then examined using the ELISA method at the Integrated Biomedical Laboratory, Faculty of Medicine, Udayana University. The results were analyzed using the chi square test. There was no significant difference in the characteristics of the two groups. There was a significant relationship between high serum cortisol levels and the incidence of preterm labor in pregnant women (p < 0.001; 95% CI; 2.768-38.22; OR 10.29). High cortisol serum levels can increase the risk of preterm labor 10 times in pregnant women when compared to pregnant women with low cortisol blood serum levels.


Keywords: ELISA, cortisol, preterm delivery

References

Chawanpaiboon S, Vogel JP, Moller AB, Lumbiganan P, Petzold M, Hogan D, Global, Regional, and National Estimates of Levels of Preterm Birth in 2014: A Systematic Review and Modelling Analysis. Lancet GlobHealth. 2019; 7: 37-46.

Cupen K, Barran A, Singh V, Dialsingh I. Risk Factors Associated with Preterm Neonatal Mortality: A Case Study Using Data From Mt. Hope Women’s Hospital in Trinidad and Tobago. Children. 2017; 4(108): 1-10.

Bandoli G, Pawlowski J, Feuer SK, Liang L, Oitman SP, Paynter R. Second Trimester Serum Cortisol and Preterm Birth: An Analysis by Timing and Subtype. J Perinatol. 2018; 38(8): 973-81.

Thau L dan Sharma S. Physiology Cortisol. [Internet] 2019 [updated 2019 Feb 15]. Stat Pearls Publishing.

Sandman CA, Glynn L, Schetter CD, Wadhwa P, Garite T, DeMet AC. Elevated Maternal Cortisol Early in Pregnancy Predicts Third Trimester Levels of Placental Corticotropin Releasing Hormone (CRH): Priming the Placental Clock. Elsevier. Peptides. 2006.

Wadhwa PD, Entringer S, Buss C, Lu MC. The Contribution of Maternal Stress to Preterm Birth: Issues and Considerations. Clin Perinatol. 2011; 38(3): 351-84.

Lee J, Fried R, Thayer Z, Kuzawa CW. Preterm Delivery as A Predictor of Diurnal Cortisol Profiles in Adulthood: Evidence from Cebu, Philippines. American Journal of Human Biology. 2014; 26: 598-602.

Giurgescu C. Are Maternal Cortisol Levels Related to Preterm Birth?. JOGNN. 2009; 38: 377-390.

Chiabi A. Mah EM, Mvondo N, Nguefack S, Mbuagbaw L, Kamga KK, et al. Risk Factors for Premature Births: A Cross-Sectional Analysis of Hospital Records in a Cameroonian Health Facility. Afr J Reprod Health. 2013; 17(4): 77-83.

Cobo T, Kacerovsky M, Jacobsson B. Risk factors for spontaneous preterm delivery. Int J Gynecol Obstet. 2020; 150: 17–23.

Goisis A, Remes H, Barclay K, Martikainen P, Myrskyla M. Advanced Maternal Age and the Risk of Low Birth Weight and Preterm Delivery: a Within-Family Analysis Using Finnish Population Registers. Am J Epidemiol. 2017; 186(11): 1219–1226.

Duffy AR, Schminkey DL, Groer MW, Shelton M, Dutra S. Comparison of Hair Cortisol Levels and Perceived Stress in Mothers Who Deliver at Preterm and Term. Biological Research for Nursing. 2018; 1-8.

Karakasha SD, Tschankoshvilib N, Weedonc J, Schwartzd RM, Kirschbaume C, Minkofff H. Hypocortisolism and preterm birth. Journal of Neonatal-Perinatal Medicine. 2016; 9: 333–9.

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How to Cite
Agung Suwardewa, T. G., Negara, K. S., Putra, I. G. M., Artana Putra, I. W., Pangkahila, E. S., & Maesa Putra, I. G. B. G. (2022). High Maternal Cortisol Serum Levels as A Risk Factor for Preterm Labor. European Journal of Medical and Health Sciences, 4(3), 75–77. https://doi.org/10.24018/ejmed.2022.4.3.1346