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The seroprevalence in Indian states Haryana and Odisha has been investigated. The seropositivity in the Haryana population increased with time from 8% to 14.8% to 76.3% as recorded in August, October 2020, and September 2021, respectively. The virus spread was continuous as the increase in seroprevalence was monotonous. The three COVID-19 pandemic waves that hit Haryana in September, November 2020, and May 2021 infected the population and generated antibodies. The last serosurvey conducted in September 2021 which registered 76.3% seroprevalence might have a contribution from vaccination as 25% of all the population was fully vaccinated and 60% had one dose. The seroprevalence in Odisha was found to be 20.8%, 68.1%, and 73% in the surveys conducted in August 2020, June, and August 2021, respectively. The survey conducted in Odisha in August 2021 found that 93% of the healthcare workers had antibodies suggested that in the general population also, 93% seroprevalence might be possible by strong vaccination drive or repeated virus exposure. A maximum seroprevalence of 75% was found in the age group of 19-44 years and the lowest of 66% was recorded among 60-plus individuals.

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