Tamsulosin And Dementia In Old Age: Is There Any Relationship?

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  •   Rebecca Renata Lapenda do Monte

  •   Karina de Andrade Vidal Costa

  •   Arnaldo Santiago Nunes Junior

  •   Amália Cinthia Meneses Rêgo

  •   Irami Araujo Filho

Abstract

Tamsulosin is used to treat Benign Prostatic Hyperplasia (BPH), prescribed annually to about 12.6 million patients worldwide. It is an alpha-adrenergic antagonist that reduces the tone of the prostate smooth muscle involved in the pathophysiology of BPH. By acting on alpha 1A receptors, predominant in the prostate, tamsulosin also acts on receptors present in the brain. This study consisted of a literature review aimed at disseminating scientific knowledge about the relationship between the use of tamsulosin and the onset of dementia. Pubmed, Scopus, Scielo, Embase, and Web of Science studies involving dementia in patients using tamsulosin in the last five years were selected. The review showed a risk correlation and a higher incidence of dementia in treated patients. The risk ratio, when compared to other medicines, approached 1.20. In conclusion, it was identified the need for clinical trials with higher sampling power to increase relational significance due to the high prevalence of BPH and the extensive use of tamsulosin in elderly patients with the disease.


Keywords: benign prostatic hyperplasia, prostatic hyperplasia, cognitive functions, tamsulosin, dementia, adrenergic alpha-1 receptor antagonists

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How to Cite
Lapenda do Monte, R. R., Vidal Costa, K. de A., Nunes Junior, A. S., Meneses Rêgo, A. C., & Filho, I. (2019). Tamsulosin And Dementia In Old Age: Is There Any Relationship?. European Journal of Medical and Health Sciences, 1(4). https://doi.org/10.24018/ejmed.2019.1.4.77